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Rethinking Sex and Gender Differences in Research: Why Sex-Based Drug Development Matters

January 29, 2025

Author:

Allison Swelin

Despite women comprising nearly half the global population – and up to 80% of patients in therapeutic areas like immunology – medical treatments have historically overlooked their unique biological needs. The traditional approach of treating women as smaller versions of men, while limiting "women's health" to reproductive functions, fails to account for fundamental biological differences.

These differences are profound and exist at multiple levels:

  • Cellular sex (every cell has a sex)
  • Hormonal influences
  • Genetic factors
  • Disease manifestation and progression
  • Treatment response

The implications extend beyond equity – understanding these distinctions is crucial for developing more precise and effective healthcare for everyone. Recent research suggests that pharmaceutical companies can play a pivotal role in closing health gaps between women and men while creating new value opportunities. This could involve:

  • Redesigning R&D approaches to account for sex-based differences
  • Improving patient journey mapping to reflect women's experiences
  • Refining commercial strategies to better serve women's health needs
  • Integrating sex-specific considerations across medical affairs

The pharmaceutical industry is at an inflection point where addressing sex-specific differences could both reduce clinical trial risks and improve health outcomes across populations. As research capabilities advance, there's growing potential to develop more targeted, effective treatments that account for biological sex differences.

For more detailed analysis, see McKinsey & Company’s full report on closing the women’s health gap in biopharma.